A New Approach to Chronic Disease
The MSIDS Foundation is advancing research that’s redefining how chronic illness is understood and treated.
Linking Lyme disease, Alzheimer’s, and other complex conditions through a 16-point model and breakthrough science.
Millions of Americans are living with chronic, complex illness, yet answers remain limited.
Between 50-60% of all Americans have one chronic disease
25% of Americans have two or more chronic illnesses
Nearly 500,000 Americans are diagnosed with Lyme disease each year
A 2025 study estimates a 42% lifetime dementia risk for adults over 55
Most treatments focus on isolated symptoms, not the full picture of what’s driving illness.
EMERGING BREAKTHROUGHS
Recent research supported by the Foundation has demonstrated:
Reversal of Alzheimer’s-related biomarkers in patients with chronic Lyme disease using targeted treatment approaches.
This represents a potential shift in how neurodegenerative conditions are studied and treated.
What if we’ve been looking at chronic disease the wrong way?
Traditional medicine treats illness one piece at a time. The MSIDS model takes a different approach.
It identifies 16 overlapping factors that may contribute to inflammation and chronic illness, from infections and immune dysfunction to environmental and metabolic influences.
This shift has the potential to:
- Improve diagnostic accuracy
- Personalize treatment approaches
- Reveal connections across conditions once thought unrelated
The Founder of The MSIDS Foundation
For over 40 years, Dr. Richard Horowitz has treated more than 13,000 patients with chronic Lyme disease and complex chronic conditions.
Through this work, one pattern became clear:
Patients weren’t dealing with one issue but multiple overlapping factors driving illness.
That insight led to the development of the MSIDS model
(Multiple Systemic Infectious Disease Syndrome).
Today, the model is:
- Published in peer-reviewed medical literature
- Validated through decades of clinical application
- Used to guide treatment for thousands of patients
What began in the clinic is now driving a new direction in research.
A major breakthrough is about to change the conversation.
A new study supported by the MSIDS Foundation has shown:
Reversal of Alzheimer’s biomarkers using a targeted treatment approach in patients with chronic Lyme disease. This has never been demonstrated before.
And it opens the door to something much bigger:
- New pathways for Alzheimer’s research
- Earlier opportunities for intervention
- A deeper understanding of chronic disease as a whole
This is where the next phase begins.
Advancing research that moves the field forward.
The MSIDS Foundation funds and supports:
- Clinical research exploring root causes of chronic illness
- Published studies contributing to the medical literature
- Collaborative research with universities and institutions
- Emerging treatment models that go beyond symptom management
We are bridging the gap between:
- Clinical observation
- Scientific validation
- Real-world patient outcomes
Be a part of what comes next.
The MSIDS Foundation is leading a multi-center research effort to validate what we’re seeing.
This includes studying:
- The connection between Lyme disease and Alzheimer’s
- The role of the 16 MSIDS factors in chronic illness
- New treatment pathways that address root causes
We are actively seeking:
Individual donors
Family foundations
Research partners
Institutional supporters
Together, We Can Move This Research Forward.
Where this leads.
If fully realized, this research could expand into a broader effort to study:
- Alzheimer’s
- Autism
- ADHD
- Chronic Fatigue Syndrome/ME, Fibromyalgia
- Long Covid
- Autoimmune illnesses like Multiple Sclerosis
- Other complex chronic conditions
All through the lens of the MSIDS model.
The goal is simple and ambitious: To uncover a unifying framework for chronic disease and improve outcomes at scale.
This Isn’t Just About One Condition.
It’s about changing how chronic disease is understood and what becomes possible because of it.